Cancer-Related Dictionary

A sentinel lymph node is the first lymph node or group of nodes where cancer cells are most likely to spread from a primary tumor. Doctors commonly examine the sentinel nodes through a procedure called a sentinel lymph node biopsy to determine if cancer has started to metastasize or spread.

Serous carcinoma is a type of cancer that originates in the epithelial cells lining certain organs, most commonly the ovaries, fallopian tubes, and the peritoneum. It is characterized by the production of a thin, watery fluid and is known for its aggressive nature and rapid spread.

Sessile serrated lesions are a type of growth found in the colon that can potentially develop into cancer. They are characterized by a flat, broad base and a saw-tooth appearance under a microscope. These lesions are considered precancerous and are often detected during routine colonoscopies.

Small molecule inhibitors are a type of medication designed to block specific enzymes or proteins in cells that contribute to disease processes, such as cancer. These drugs are typically small enough to enter cells easily and interfere with the function of target molecules, helping to slow or stop the progression of diseases.

Small cell lung cancer is a fast-growing type of lung cancer usually caused by smoking. It typically starts in the bronchi, quickly spreads throughout the body, and manifests with symptoms such as cough, chest pain, and shortness of breath. Treatment options include chemotherapy, radiation therapy, and surgery. This cancer represents about 10 -15% of all lung cancers.

Soft tissue sarcoma is a rare type of cancer arising from the soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. It can occur in any part of the body, however, it is most commonly found in the arms, legs, chest, or abdomen. Prompt diagnosis and treatment are crucial for managing this condition effectively.

Spindle cell carcinoma is a rare type of cancer characterized by spindle-shaped cells that can appear in various parts of the body, often resembling sarcomas due to their shape. It typically occurs in the skin or soft tissues and can be aggressive, requiring prompt medical attention.

Splenic lymphoma is a type of cancer that originates in the lymphatic tissue of the spleen, a vital organ involved in filtering blood and supporting the immune system. It is characterized by the uncontrolled growth of lymphocytes, a type of white blood cell.

Sporadic cancer refers to cancer that occurs by chance and is not associated with inherited genetic mutations. Most cancers are sporadic, meaning they arise from genetic changes acquired during a person's lifetime due to environmental factors or random cell mutations.

Squamous metaplasia is a process where one type of mature cell is replaced by another type of mature cell. This usually occurs as an adaptation to chronic irritation or inflammation, where glandular cells transform into squamous cells, which are more resistant to such conditions.

"Squamous cell carcinoma" is a prevalent type of skin cancer that originates from squamous cells. These cells form the outer layer of the skin's epidermis. The condition is commonly caused by prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds. It often exhibits as a firm, red nodule, or a flat lesion with a scaly, crusty surface. Though primarily appearing on sun-exposed areas, it can occur anywhere on the body. Early diagnosis and treatment are vital in preventing its spread.

"Staging" in the healthcare context, refers to the process of determining the size and spread of a specific disease or cancer within the patient's body. It facilitates the development of an appropriate treatment plan, and helps predict patient prognosis. The stage is often denoted by Roman numerals I, II, III, or IV.

A stem cell transplant, also known as a bone marrow transplant, is a medical procedure where damaged or diseased bone marrow is replaced by healthy stem cells. These cells can regenerate into new bone marrow that produces normal blood cells. This procedure may be necessary in treatment of certain cancers, blood disorders or immune deficiency syndromes.

Stereotactic radiosurgery is a non-surgical procedure that uses detailed imaging techniques and multiple streams of precise, high-energy radiation to treat tumors and other abnormalities in the brain, spine, lungs or other body parts, without harming the surrounding healthy tissue. It minimizes side effects and allows for a swift recovery.

"Steroid therapy" refers to the medical use of steroid hormones, either naturally occurring or synthetic, to treat diseases and conditions. Steroids can reduce inflammation, suppress immune system response, and balance hormones. They're used in conditions like asthma, arthritis, autoimmune diseases, and cancer. Steroid treatment must be managed carefully due to potential side effects.

A "Stoma" is a medical term referring to an artificially created opening in the body, often established during surgical procedures. It serves as a direct pathway for waste elimination from the body or breathing, mainly in cases where natural processes have been hindered due to health conditions. Typical types include colostomy, ileostomy, and tracheostomy.

Superficial spreading melanoma is a common type of skin cancer that begins in the pigment-producing cells of the skin. It typically appears as a flat or slightly raised discolored patch with irregular borders and can grow outward across the surface of the skin before penetrating deeper layers.

"Surgery" refers to the medical field that uses operative techniques to investigate or treat physical conditions. It involves cutting, ablation, suturing or otherwise physically altering body tissues and organs, frequently performed to remove or repair damaged parts. Types of surgery can range from minor procedures to complex major surgeries. It often ventures into science, art, and technology.

Surgical staging is a procedure used to determine the extent of cancer spread within the body. It involves a surgeon examining tissues, organs, and sometimes lymph nodes during surgery to assess how far the cancer has progressed. This information helps doctors plan the most effective treatment strategy.

A surgical oncologist is a specialist in the field of oncology, responsible for the surgical removal of tumors and cancerous tissues. They work as part of a multidisciplinary team, providing surgical interventions, performing biopsies, and contributing to treatment planning for cancer patients. Their expertise lies in cancer surgery and understanding tumor biology.

Survivorship care refers to the comprehensive healthcare and support provided to individuals who have completed initial cancer treatment. It focuses on monitoring for recurrence, managing long-term side effects, and addressing psychosocial needs to help survivors lead healthy lives.

Systemic therapy refers to the use of medication or treatment that affects the entire body rather than a specific area or part. It is commonly used to treat diseases that have spread throughout the body, such as cancer, by circulating through the bloodstream to reach cells in various locations.

A T-cell, also known as a T-lymphocyte, is a type of white blood cell that plays a fundamental role in the immune system. T-cells primarily perform the role of identifying and destroying abnormal or infected cells, including bacteria and viruses, to protect the body from infection or disease. They also aid in stimulating other immune responses. The 'T' stands for thymus, the gland in which these cells mature.

Testicular cancer is a type of malignancy that originates in the testicles, which are male reproductive organs producing sperm and hormones. This condition, while rare compared to other cancers, is the most common cancer in American men aged 15-35. It's highly treatable, often curable, but early detection is crucial for better prognosis and recovery.

Thymic carcinoma is a rare type of cancer that originates in the thymus gland, located in the upper chest. Unlike thymomas, which are typically benign, thymic carcinomas are malignant and can spread to other parts of the body.

A thyroid lobectomy is a surgical procedure where one lobe (half) of the thyroid gland is removed. This is often done when there is a suspicious nodule or tumor, or for treating certain thyroid conditions.

Thyroid cancer is a type of malignancy that begins in the thyroid gland, a butterfly-shaped organ at the base of the throat responsible for hormone production. Symptoms often include a lump in the neck, voice changes, difficulty swallowing, or unexplained weight changes. Treatment depends on the stage and type of cancer but can include surgery, radioactive iodine therapy, hormonal therapy, and chemotherapy. Early detection allows for a high survival rate.

Tissue microarrays are a laboratory technique used to analyze multiple tissue samples simultaneously on a single slide. This method allows researchers to study the expression of proteins or genes in various tissues efficiently, making it a valuable tool in cancer research and pathology.

Tomotherapy is a unique type of radiation therapy used in cancer treatment. It combines the precision of 3D imaging with rotational delivery of radiation, precisely targeting the tumor from all angles. This technique helps to minimize exposure to healthy tissue, thereby reducing side effects. Tomotherapy offers the advantage of adjusting doses to match a tumor’s size, shape and location.

Topoisomerase inhibitors are medications that interfere with the action of topoisomerase enzymes, which help manage the structure of DNA during cell division. These inhibitors are primarily used in cancer treatment to prevent cancer cells from proliferating.

"Transition" refers to the process or period of changing from one state, condition, or place to another. It can relate to personal developments, such as life transitions, or wider societal changes. It can also pertain to the movement in writing or speech from one point or topic to another, ensuring logical coherence and flow.

Transoral robotic surgery is a minimally invasive surgical technique that uses robotic systems to remove tumors or perform procedures in the mouth and throat through the mouth, without external incisions.

Triple-negative breast cancer (TNBC) refers to a subtype of breast cancer characterized by the absence of estrogen, progesterone, and HER2 receptors, making it less responsive to hormonal therapies. This type of cancer is often more aggressive and has a higher risk of recurrence compared to other types, requiring specialized treatment strategies.

A tumor refers to a mass or lump of abnormal cells in the body which can be benign (non-cancerous), pre-malignant (pre-cancerous), or malignant (cancerous). Tumors can occur anywhere in the body and may grow slowly or rapidly. They may cause symptoms due to their size or location, or can be asymptomatic. Tumors are generally diagnosed through imaging tests, biopsies, and other medical examinations.

A tumor board is a group of medical experts from various specialties who collaborate to discuss and plan the best treatment approach for patients with complex cancer cases. This multidisciplinary team typically includes oncologists, radiologists, pathologists, surgeons, and other healthcare professionals.

Tumor burden refers to the total amount of cancer present in a person's body. It includes the size of the tumor, the number of cancerous cells, and the extent to which cancer has spread to other parts of the body.

Tumor progression refers to the process by which a tumor grows and potentially becomes more aggressive, spreading to other parts of the body. This involves changes at the cellular level, where cancer cells divide uncontrollably, invade nearby tissues, and may metastasize to distant organs.

Tumor vasculature refers to the network of blood vessels that supply nutrients and oxygen to a tumor, enabling its growth and survival. This vascular system is often abnormal compared to normal tissue vasculature, with irregular structure and function.

Tumor markers are substances, often proteins, found in blood, urine, and tissue, produced by cancerous cells or by the body in response to cancer. They are valuable as they can indicate the presence, type, and progression of a malignancy. However, these markers are not entirely specific to cancer and can be elevated in non-cancerous conditions.

Tumor suppressor genes are a type of gene that makes a protein called a tumor suppressor protein, which helps regulate cell division. These genes primarily function to prevent cells from growing and dividing too rapidly or in an uncontrolled way, playing a vital role in preventing cancer. Mutations or abnormalities in these genes could lead to uncontrolled cell growth, leading to cancer.

Tumor-infiltrating lymphocytes (TILs) are immune cells that have moved from the bloodstream into a tumor. They are part of the body's natural defense system and can recognize and attack cancer cells, which can help in slowing down or stopping tumor growth.

Ultrasound is a medical imaging technique that utilizes high-frequency sound waves to create images of internal body structures, such as organs, tissues, or blood flow. It's a non-invasive and safe diagnostic method used widely in medicine, particularly in obstetrics for pregnancy monitoring and diagnosis of related conditions.

An ultrasound-guided biopsy is a medical procedure where a doctor uses ultrasound imaging to guide a needle to a specific area of the body to collect a tissue sample for examination. This technique helps ensure accuracy and minimize damage to surrounding tissues.

Urethral cancer is a rare type of cancer that occurs in the urethra, the tube that carries urine from the bladder out of the body. It can cause symptoms such as difficulty urinating, blood in the urine, and pelvic pain.

Uterine cancer refers to a type of cancer that begins in the uterus, the pear-shaped organ in a woman's pelvis where fetal development occurs. It primarily affects postmenopausal women and it's typically caused by cells growing uncontrollably. The two main types are endometrial cancer (most common, starts in the uterus lining) and uterine sarcoma (rare, begins in the muscle). Early diagnosis and treatment are crucial for effective management.

Vaccine therapy is a treatment approach that uses vaccines to stimulate the body's immune system to fight diseases, particularly infections and certain types of cancer.

Valrubicin is a chemotherapy drug used primarily to treat bladder cancer that has not responded to other treatments. It works by interfering with the growth of cancer cells, slowing or stopping their spread.

Vascular sarcoma is a rare type of cancer that originates in the cells that make up blood vessels. It can occur in any part of the body but is most commonly found in the skin, liver, or deep tissues. This cancer is known for its aggressive nature and potential to spread quickly to other parts of the body.

Vascular endothelial growth factor (VEGF) is a protein that stimulates the growth of blood vessels. More specifically, it promotes angiogenesis (the formation of new blood vessels from pre-existing ones), vascular permeability, and endothelial cell growth. It plays a significant role in various biological processes, such as embryonic development and wound healing, but is also implicated in diseases like cancer.

VEGF inhibitors are medications that block the action of vascular endothelial growth factor (VEGF), a protein that promotes blood vessel formation. These inhibitors are used to treat various conditions, primarily certain types of cancer and eye diseases, by restricting the growth of blood vessels that supply nutrients to tumors or affect vision.