Cancer-Related Dictionary

Peritoneal carcinomatosis is a condition where cancer cells spread to the peritoneum, the lining of the abdominal cavity. This often occurs in advanced stages of abdominal cancers such as ovarian, gastric, or colorectal cancer, leading to symptoms like abdominal pain, bloating, and weight loss.

Phlebotomy is a healthcare process that involves drawing blood from patients for various purposes such as medical testing, donations, or research. This procedure is typically performed by a phlebotomist, a specialized medical professional trained to collect blood samples correctly and safely.

Photodynamic Therapy (PDT) is a medical treatment method which uses light-sensitive compounds, activated under specific light to destroy abnormal cells or pathogens. Widely used to tackle cancers and severe skin conditions, the therapy selectively damages the targeted cells while sparing healthy ones.

A placebo is a harmless, inactive substance or treatment given to a patient, often used in clinical trials as a control group. It's designed to resemble actual medication in appearance and administration, without therapeutic effects. Its aim is to measure the impact of belief on health outcomes and to isolate the efficacy of the actual treatment under consideration.

Plasmacytoma refers to a malignant tumor formed by abnormal plasma cells, which are a type of white blood cells responsible for producing antibodies. These tumors often occur in the bone marrow and soft tissues. Although they are generally observed as isolated lesions, their occurrence could be an early sign of multiple myeloma, a cancer of plasma cells.

A "platelet count" is a lab test that measures the number of platelets, which are small blood cells that help in blood clotting, in a person's blood. It is used to diagnose diseases and monitor treatment effectiveness. Low or high platelet counts can indicate a medical condition that requires treatment.

Platelets, also known as thrombocytes, are small, colorless cell fragments in our blood that form clots and stop or prevent bleeding. These essential components of the blood are produced in the bone marrow and serve a crucial role in blood coagulation, wound healing, and inflammation response.###

Pleomorphic adenoma is a benign tumor that typically occurs in the salivary glands, most commonly in the parotid gland. It is characterized by a mix of different cell types and structures, hence the name 'pleomorphic.' While generally non-cancerous, it can become malignant if not treated.

A polyp is a small, abnormal growth of tissue that develops on the lining of a body part, such as the cervix, colon, or nasal passage. Typically benign (non-cancerous), polyps can sometimes become malignant (cancerous). Their size, number, and location can influence the treatment approach.

"Precancerous" refers to cells that have abnormal changes and might transform into cancer over time, but are not yet cancerous themselves. This term is often used to describe conditions that significantly increase the risk of cancer, such as certain types of skin lesions or polyps in the colon. However, not all precancerous conditions will necessarily develop into cancer.

"Preclinical" refers to the phase of research conducted before a new drug or treatment is tested on humans. This stage involves laboratory experiments using cell cultures and animal testing to determine the efficacy, potential side effects, and optimal dosage. It is a fundamental step in drug development and policy-making in healthcare.

A primary tumor is the original growth of cancer cells that initially forms in the body. It is typically the first indication or onset of cancer within a specific organ or tissue. The primary tumor can metastasize, spreading to different body parts, resulting in secondary tumors. Treatments often target the primary tumor first to stop further spread of cancer.

Prognosis refers to the likely course or outcome of a disease, condition, or patient's recovery based on the general outlook of the identified condition. It provides estimates about chances of recovery, disease progression, and survival rates based on factors such as patient's health, type of disease and treatment.

Prognostic factors are specific characteristics that help predict the likely outcome or course of a disease in a patient. These factors can include age, stage of disease, and specific biological markers, and they assist healthcare providers in determining the best treatment approach.

Progression-Free Survival (PFS) is a medical term used in oncology to denote the length of time during and after treatment, a patient lives with a disease that does not worsen. It's an essential measure in assessing the efficacy of new cancer treatment drugs or methodologies.

Prolactin is a hormone produced by the pituitary gland, primarily responsible for stimulating milk production after childbirth. Also, it plays a role in fertility by inhibiting follicle-stimulating hormone (FSH) and gonadotropin-releasing hormone (GnRH). Elevated levels can cause reproductive problems in both men and women.

A prophylactic mastectomy is a preventive surgical procedure performed to remove one or both breasts to minimize the risk of developing breast cancer. It is typically considered by individuals with a high risk of breast cancer due to genetic mutations or a strong family history of the disease.

Prostate cancer is a medical condition characterized by abnormal growth of cells in the prostate gland, a tiny walnut-shaped organ present in males, responsible for semen production. It's one of the most prevalent types of cancer among men and can vary from slow-growing to aggressive, potentially metastasizing to other body parts if left untreated. Risk factors include age, family history, race, and certain dietary habits.

Protein biomarkers are specific proteins found in the body that can be measured and used to indicate a biological state, such as the presence of a disease or condition. They help in diagnosing diseases, predicting disease progression, and monitoring treatment responses.

Proton therapy is an advanced type of radiation treatment that uses high-energy proton beams instead of conventional X-rays to eradicate cancer cells. By precisely targeting tumors, proton therapy minimizes damage to healthy tissues and organs, potentially reducing side effects and improving patient outcomes.

Psycho-oncology (from psychology and oncology) refers to the psychological care of cancer patients and survivors (cancer counseling). Another term is psychosocial oncology. Psycho-oncology is thus an interdisciplinary form of psychotherapy or clinical psychology that deals with the psychological, social, and socio-legal conditions, consequences, and concomitant symptoms of cancer. In the practical context of care or therapy, it is the responsibility of the psychooncologist to support the patient in coping with the disease by means of different techniques, for example, crisis intervention or resource-oriented interventions. The aim here is to strengthen the patient's competence to cope with the illness. Psycho-oncological care should be ensured in all phases of the disease, i.e. during acute treatment, rehabilitation, and, also after successful treatment.

The term "psychosocial" refers to the combined influence of psychological and social factors on an individual's overall well-being and functioning. It encompasses the interplay between a person's mental or emotional state (psychological) and the various aspects of their social environment, including relationships, cultural context, and societal influences. The psychosocial approach considers the dynamic interaction between an individual's inner experiences and the external social factors that shape and impact their mental health, behavior, and overall quality of life.

Pulmonary metastases refer to cancer cells that have spread from a primary tumor located in another part of the body to the lungs. This process is known as metastasis, and it indicates that the cancer is at an advanced stage.

Quality of Life (QoL) refers to the overall well-being of an individual, encompassing both physical and mental states, including health, happiness, job satisfaction, family life, education, and safety. It is a broad concept impacted by various individual life factors, often used to evaluate the general well-being in different societies and cultures.

Quantitative PCR (qPCR), also known as Real-Time PCR, is a molecular biology technique used to amplify and simultaneously quantify DNA in real time. The main benefit of qPCR over traditional PCR is its ability to detect the specific sequences during the phase of exponential amplification, making it more efficient and accurate for DNA analysis and cloning tasks.

Radiation fibrosis syndrome is a condition that occurs when healthy tissue becomes scarred and stiff after exposure to radiation therapy, commonly used in cancer treatment. This can lead to a range of symptoms depending on the area affected, including pain, restricted movement, and functional impairments.

Radiation necrosis is a condition where healthy tissue is damaged and dies as a result of exposure to radiation therapy, typically used in cancer treatment. This can lead to symptoms such as swelling, neurological deficits, and other complications depending on the area affected.

A Radiation Oncologist is a medical professional specialized in the use of radiation therapy to treat various types of cancer. They plan and administer the right dosage of radiation to accurately target the cancerous cells while minimizing damage to surrounding healthy tissues. They collaborate with other physicians in a multidisciplinary team to provide holistic cancer care.

Radiation therapy is a type of cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. It can be delivered externally via machines outside the body, or internally, where radioactive material is placed in the body near cancer cells. This treatment aims to damage the DNA of cancer cells, preventing them from growing and dividing.

A radical mastectomy is a surgical procedure aimed at breast cancer treatment. In this operation, the entire breast, chest muscles beneath it, and all the lymph nodes under the arm are removed. It was once the standard treatment, but less extensive surgeries are typically performed today.

Radiotherapy, also known as radiation therapy, is a type of cancer treatment that uses high-energy radiation to destroy cancer cells. It can be delivered externally by a machine that targets the affected area, or internally through the insertion of radioactive material into the body. It's designed to kill cancerous cells while minimizing damage to healthy tissues.

Rare cancers are types of cancer that occur infrequently, affecting a small percentage of the population. They can be challenging to diagnose and treat due to limited research and awareness.

"Receptor status" refers to the presence or absence of particular proteins (receptors) on the surface of cancer cells. These receptors influence how the cancer behaves and responds to treatment. They are typically identified in laboratory tests, helping doctors guide the most effective treatment. Common examples include hormone receptors in breast cancer and human epidermal growth factor receptor-2 in certain types of cancers.

Rectal cancer is a disease in which malignant (cancerous) cells form in the tissues of the rectum. The rectum is the last several inches of the large intestine. It often manifests with symptoms like persistent change in bowel habits, rectal bleeding or blood in stool, persistent abdominal discomfort, and unexplained weight loss. Early diagnosis aids effective treatment.

Recurrence refers to the act of occurring again or repeating. In a health context, it often refers to the return of a disease or condition after a period of improvement or apparent cure. It can also apply to repeated patterns or events in various other disciplines, such as mathematics, engineering, or computer science.

Refractory cancer is a type of cancer that does not respond to treatment. It may continue to grow or spread despite therapy, making it challenging to manage.

Regulatory science is a science that develops the (technical) foundations, processes, methods, and tools to formulate regulatory requirements that ensure the safety, performance, and efficacy of pharmaceuticals and medical devices. It encompasses basic and applied biomedical and social sciences and contributes to the development of regulatory standards and tools.

Remission refers to the state where the signs and symptoms of a disease or condition temporarily or completely disappear. It's often used in context to chronic or severe diseases like cancer, indicating a period where the disease is under control or undetectable. However, remission doesn't necessarily mean a cure, as the disease can return.

Renal angiomyolipoma is a benign tumor of the kidney composed of blood vessels, muscle, and fat. It is usually non-cancerous and often goes undetected unless it causes symptoms or complications.

Renal cancer, also known as kidney cancer, is a disease characterized by the abnormal and uncontrollable growth of cells in the kidneys, vital organs that filter waste from the blood. The most common type is renal cell carcinoma. Symptoms may include blood in the urine, back pain, and fatigue. Late detection or diagnosis could lead to the disease spreading to other organs. Treatment varies depending on the stage and may include surgery, radiation, or targeted therapy.

Residual disease refers to the small amount of cancer cells that may remain in the body after treatment, which can lead to a recurrence if not effectively managed.

Retroperitoneal sarcoma is a rare type of cancer that develops in the connective tissues located in the retroperitoneal space, an area in the back of the abdomen behind the peritoneum, which is the lining of the abdominal cavity. These tumors can grow quite large before causing symptoms, as they have space to expand in the retroperitoneal area.

Risk stratification is a process used in healthcare to categorize patients based on their risk of developing certain diseases or complications. It helps doctors prioritize care and tailor treatments based on the level of risk.

Sarcoma is a type of malignant tumor that arises from transformed cells of mesenchymal (connective tissue) origin. It can occur in various locations in the body, including the bones, muscles, tendons, cartilage, nerves, fat, and blood vessels. Despite being relatively rare, sarcomas are aggressive and often require intense treatment modalities such as surgery, radiation, and chemotherapy.

Sarcomatoid carcinoma is a rare type of cancer that exhibits both carcinoma and sarcoma characteristics. It is an aggressive tumor that can occur in various organs and tissues, often presenting challenges in diagnosis and treatment due to its mixed cellular components.

Secondary cancer, also known as metastatic cancer, occurs when cancer cells spread from the original (primary) site to another part of the body. This process involves the movement of cancer cells through the bloodstream or lymphatic system, leading to the formation of new tumors in other organs or tissues. Secondary cancers retain the name of the primary cancer type, even though they appear in a different location.

Secondary malignancies are new cancers that occur in a person who has previously been diagnosed with cancer. These are not recurrences of the original cancer but entirely new types of cancer that develop as a result of the initial cancer treatment, genetic predisposition, or other risk factors.

The semen analysis is the most important test available to evaluate male fertility. To do this, one needs to provide a semen sample. In a laboratory, a drop of semen is examined under a microscope and the number (sperm count), shape (morphology), and mobility (movement) of the sperm are determined. Sperm count: Either >16 million per ml or a total of over 39 million per ejaculation is considered normal. Shape: At least 4% must have a normal shape. The head, the midpiece, and the tail of the sperm are assessed. Mobility: More than 42% of sperm need to move and more than 30% need to travel. Movement is classified as progressive (purposeful forward movement), non-progressive (local movement, circular movement), or immotile (no movement).

A sentinel lymph node biopsy is a surgical procedure used to determine if cancer has spread beyond a primary tumor into the lymphatic system. It involves identifying, removing, and examining the sentinel lymph nodes, which are the first nodes to which cancer cells are likely to spread from a primary tumor.

Sentinel node mapping is a medical procedure used to identify the first lymph node, known as the sentinel node, that cancer cells are most likely to spread to from a primary tumor. This technique helps doctors determine the extent of cancer spread and plan appropriate treatment.