The EU General Data Protection Regulation (GDPR) 1 was implemented on May 25, 2018, stipulating rules on the protection of individuals regarding the processing and free movement of personal data. 3 years later, the European Society for Paediatric Oncology (SIOP Europe) conducted a survey among clinicians and academics from across Europe to investigate the impact of the GDPR on childhood cancer research and to identify the challenges and opportunities in this field.