Try adjusting your type
14th October, 2009
European Survey on Standards of Care in paediatric oncology centres. J. R. Kowalczyk, M. Samardakiewicz, K. Pritchard-Jones, R. Ladenstein, S. Essiaf, E. Fitzgerald, G. Petrarulo, G. Vassal - EJC , Volume 61, pp 11-19
8th December, 2014
The purpose of this website is to provide good and clear information about the long-term effects of childhood cancer and to refer to the various late-effects outpatient clinics (LATER outpatient clinics) that exist in the Netherlands.
8th September, 2015
Cancer in young people is rare, but it is still a major health issue in Europe. Each year, more than 6,000 young people in Europe die of cancer. There are more than 300,000 European childhood cancer survivors (in 2020, they will be nearly half a million): two-thirds of them have some late side effects of treatment, that are severe and impact on the daily life of half of those affected.
Merkel cell carcinoma (MCC) refers to a rare and aggressive type of skin cancer that typically begins in the hormone-producing cells just beneath the skin and hair follicles. It commonly appears as a flesh-colored or bluish-red nodule and usually develops on sun-exposed areas. While MCC can occur at any age, it predominantly affects seniors and those with a weak immune system.
Among the myriad types of skin cancer witnessed across the globe, Merkel Cell Carcinoma stands out due to its rarity and aggressive nature. Unraveling its mysteries, comprehending its origins, identifying its symptoms, and discovering efficacious treatments is not just a matter of scientific intrigue but a vital medical necessity. Let’s delve into this topic for a comprehensive understanding of this unique type of skin cancer.
Merkel Cell Carcinoma (MCC) is an uncommon type of skin cancer that typically begins in cells situated close to nerve endings beneath the skin surface. These cells, known as Merkel cells, are believed to play a crucial role in the skin’s ability to perceive touch.
Frequently, MCC appears as a single painless lump that tends to grow rapidly. Regrettably, due to its rapid evolution and potential to metastasize, this malignancy poses a significant risk to health, necessitating an urgent focus on early detection and management measures.
The exact etiology behind MCC remains problematic. Nonetheless, the research identifies two major culprits—prolonged sun exposure and the Merkel Cell Polyomavirus. The ultraviolet light emitted by the sun can damage the skin’s DNA, inciting changes that may lead to abnormal growth and malignancies, including MCC.
On the other hand, Merkel Cell Polyomavirus, a generally harmless virus present in most adult populations, under certain conditions, can trigger rapid cell growth, leading to MCC. Additional risk factors include a weakened immune system, advancing age, and pale skin that burns easily.
MCC typically manifests as a reddish or violet painless lump that grows rapidly. Other signs may include skin changes, such as redness, sores, or scaling. However, these symptoms are non-specific and can mimic other skin conditions.
Diagnosis typically involves an initial skin examination, followed by a biopsy to determine the cell’s type and morphological features. Imaging tests such as CT scans or PET scans can provide further insights into the extent of the disease.
Treatment for MCC consists of a multidimensional approach. Surgical excision of the tumor is the initial line of attack. However, due to the disease’s propensity to metastasize, adjuvant therapy including radiation and chemotherapy is often necessary.
Immunotherapy, an emerging treatment modality, specifically aims to stimulate the body’s immune system to fight cancerous cells effectively. It holds promise as a potent weapon, particularly in advanced MCC.
The prognosis for MCC depends on several factors, including tumor size, stage at diagnosis, and overall health status. Despite its aggressive nature, early detection and targeted treatment can significantly improve outcomes. Current research and trials are keenly focused on enhancing understanding and shaping more effective treatments for MCC.
The battle against MCC is a reminder of the significance of early detection, prompt treatment, and ongoing research. Although this malignant disease can be threatening, comprehensive understanding, timely action, and advances in therapy can provide a beacon of hope.
MCC typically appears as a rapidly growing, painless lump on the skin. The lump might be red or violet in color.
MCC is rarer and generally more aggressive than most skin cancers. It originates from Merkel Cells, which are located near nerve endings underneath the skin.
MCC, due to its aggressive nature, can spread rapidly to other parts of the body, leading to severe complications.
Minimizing exposure to the sun, practicing regular skin checks, and maintaining a robust immune system can help lower your risk.
The curability often depends on the stage at diagnosis and overall health status. Early detection significantly improves survival rates.
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