Cancer Dictionary

Adenopathy refers to the medical condition characterized by the abnormal enlargement of the lymph nodes, which are vital parts of the immune system. The swelling may be due to infections, chronic inflammatory conditions, or malignancies. It's often detected through physical examination or imaging studies.

Adolescents and Young Adults (AYA) is a term typically used in healthcare to denote a specialized group ranging from ages 15 to 39. This group experiences unique health issues, including specific cancers and mental health disorders, which may require distinct treatment strategies and healthcare models.

Allogeneic refers to cells, tissues, or organs that are sourced from a genetically different individual of the same species. In healthcare, it often describes donor material for transplants such as Allogeneic Stem Cell Transplant, where donor stem cells are introduced to the recipient to aid disease treatment.

Alopecia, also known as hair loss, is a medical condition that involves the thinning or complete loss of hair from areas where it normally grows. This can affect the scalp, face, and body, and can occur due to various factors including genetics, hormonal changes, immune system abnormalities, or as a side effect of certain treatments or medications.

Hypofractionation is a method used in radiation therapy where the total dose of radiation is divided into large doses and treatments are given less often than traditional radiation therapy. This approach minimizes the treatment duration, potentially enhancing the convenience and effectiveness of the therapy.

Aplastic anemia is a rare, serious blood disorder in which the body's bone marrow fails to produce enough new blood cells, leading to a deficiency in all three blood cell types: red blood cells, white blood cells, and platelets. This condition can lead to uncontrolled bleeding, increased susceptibility to infections, and constant fatigue. It can occur at any age, sometimes without known cause.

"Anaplastic" is a term often used in the medical field, particularly in oncology, to describe cancer cells that have lost their distinct characteristics and appear undifferentiated. These cells exhibit irregular growth and lack the typical specialized features of healthy cells, often making the disease more aggressive and harder to treat.

Androgen is a type of hormone that plays a crucial role in the development and maintenance of male characteristics in mammals. It includes hormones like testosterone and dihydrotestosterone, which are produced primarily in male testes and female ovaries to regulate sexual development, muscle mass, bone density, and hair growth.

Anemia is a medical condition characterized by a deficiency in red blood cells or hemoglobin in the blood, leading to a lack of oxygen reaching the body's tissues. Hemoglobin is responsible for carrying oxygen, so any insufficiency can cause fatigue, weakness, and shortness of breath. Anemia can be temporary or long-term, and range from mild to severe. It's important to diagnose and treat anemia to handle any underlying causes and to prevent further health problems.

Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing ones. Predominantly occurring during development, wound healing, and the formation of granulation tissue, it's also a critical step in the transition of tumors from a benign state to a malignant one.

Asbestos is a naturally occurring mineral that has heat-resistant properties. It was widely used in construction and manufacturing due to its strength and fire-resistant qualities. However, its fibers can cause serious health issues, like lung cancer and mesothelioma, when inhaled or ingested, leading to its ban in many countries.

Asparaginase is a therapeutic enzyme used in medical treatment, particularly in the management of acute lymphoblastic leukemia (ALL). It functions by breaking down asparagine, an amino acid crucial for cell growth, thereby inhibiting the proliferation of malignant cells that rely heavily on asparagine.

Basal cells are a type of cell found at the bottom layer of the skin, known as the epidermis. These cells are responsible for skin regeneration, producing new skin cells and pushing older cells upward. Abnormal growth of basal cells can lead to basal cell carcinoma, the most common type of skin cancer.

"Benign" refers to a condition, tumor, or growth that is not harmful in effect and not malignant. It is non-cancerous and does not spread to other parts of the body. It denotes a mild form or consequence that does not typically become life-threatening or seriously damaging. In healthcare, benign is often associated with a positive prognosis.

Beta Human Chorionic Gonadotropin (Beta HCG) is a hormone produced by cells that are associated with pregnancy. It's usually detected in blood tests or urine tests to confirm pregnancy or as part of a screening test for certain birth defects. It can also be used in medical diagnostics to detect some cancers.

A brain tumor is an abnormal growth or mass of cells within the brain. These tumors can be either benign (non-cancerous) or malignant (cancerous) and can originate from the brain tissue itself or from other parts of the body, spreading to the brain. The presence of a brain tumor can disrupt normal brain function by compressing surrounding structures, causing neurological symptoms, and potentially leading to serious health issues. Diagnosis and treatment of brain tumors involve various medical interventions, such as imaging studies, surgery, radiation therapy, and chemotherapy, depending on the type, location, and characteristics of the tumor.

Cancer Stage (I, II, III, IV) refers to the extent of cancer spread in the body, determined by the size and location of the tumor, lymph node involvement, and whether the disease has metastasized. Stage I usually indicates a small tumor confined to the origin site. Stage II and III show larger tumors or greater spread to nearby tissues and nodes. Stage IV symbolizes advanced cancer that has spread to distant parts of the body.

Carcinoma is a type of cancer that starts in cells making up the skin or the tissue lining organs, such as the liver or kidneys. Unlike sarcomas, carcinomas originate in epithelial cells, including those in glandular tissues. These cancers can affect many parts of the body, often leading to specific symptoms based on their location and stage. Treatment typically involves a combination of surgery, radiation, and chemotherapy.

A "Complete response" in a healthcare context typically refers to the total disappearance of all detectable signs and symptoms of disease, often as a result of treatment. It indicates a positive outcome where the individual shows no further evidence of the illness. However, it doesn't guarantee that the disease is permanently cured. It's an important effect reported in clinical trials and cancer treatment.

"Cribriform" is a term used in anatomy and histology, referring to a structure that appears perforated or sieve-like. The term is frequently used to describe a structural pattern characterized by numerous round, small openings - resembling a sieve. This term is often mentioned with the cribriform plate of the ethmoid bone in the skull or in pathological processes like cribriform carcinoma.

DNA, short for Deoxyribonucleic Acid, is a vital molecule found in all living organisms. It contains the unique genetic code that determines the traits of a living being. Structured in a double helix shape, DNA contains pairs of nucleotides, which form genes, the basic units of heredity.

"Hormone Receptor Status" refers to a clinical parameter determined in patients with certain types of cancers. It reveals whether the patient's cancer cells express specific proteins (hormone receptors) like estrogen and progesterone, signifying their dependency on these hormones for growth. This information influences the selection of optimal therapeutic strategies, informing decisions on hormone therapy use.

CA 19-9, or Carbohydrate Antigen 19-9, is a tumor marker primarily used to monitor treatment response and disease recurrence in pancreatic cancer patients. It can also be elevated in other gastrointestinal cancers and conditions such as cirrhosis and pancreatitis. It's not recommended for cancer screening in asymptomatic individuals due to non-specific findings.

A primary tumor is the original growth of cancer cells that initially forms in the body. It is typically the first indication or onset of cancer within a specific organ or tissue. The primary tumor can metastasize, spreading to different body parts, resulting in secondary tumors. Treatments often target the primary tumor first to stop further spread of cancer.

A surgical oncologist is a specialist in the field of oncology, responsible for the surgical removal of tumors and cancerous tissues. They work as part of a multidisciplinary team, providing surgical interventions, performing biopsies, and contributing to treatment planning for cancer patients. Their expertise lies in cancer surgery and understanding tumor biology.

Prolactin is a hormone produced by the pituitary gland, primarily responsible for stimulating milk production after childbirth. Also, it plays a role in fertility by inhibiting follicle-stimulating hormone (FSH) and gonadotropin-releasing hormone (GnRH). Elevated levels can cause reproductive problems in both men and women.

Bone metastasis refers to the condition wherein cancer cells from the primary site (like breast, lung, or prostate) spread to the bones. This is a common occurrence in advanced stages of cancer, causing pain, fractures and other complications. The occurrence of bone metastasis often indicates a poorer prognosis for cancer patients.

Oncogenes are genes that can potentially cause cancer. When they are normal, they help to regulate cell growth and division. However, when they are altered or mutated, they can lead to abnormal cell growth and proliferation, eventually fostering the development of cancer.

An erythrocyte, also known as a red blood cell, plays a fundamental role in the body's circulatory system by transporting oxygen from the lungs to body tissues. These biconcave-shaped cells, packed with hemoglobin, allow them to bind with and carry oxygen and carbon dioxide. They lack nuclei, making more room for hemoglobin. Erythrocytes, a vital component of blood, give it a characteristic red color.

Mitosis is a process of cell division that results in two genetically identical daughter cells developing from a single parent cell. This is a fundamental process for growth, development, and repair in multi-cellular organisms. In essence, mitosis ensures each new cell has the same DNA as the original.

"Receptor status" refers to the presence or absence of particular proteins (receptors) on the surface of cancer cells. These receptors influence how the cancer behaves and responds to treatment. They are typically identified in laboratory tests, helping doctors guide the most effective treatment. Common examples include hormone receptors in breast cancer and human epidermal growth factor receptor-2 in certain types of cancers.

Apoptosis is a programmed cell death mechanism in the body, operating as a natural process of destructing old, faulty, or harmful cells. It's crucial for maintaining the balance in various bodily functions, from embryonic development to adult homeostasis. It's often subject to research in disease contexts, notably cancer, where apoptosis regulation fails.

A growth factor is a naturally occurring substance, often a protein, that plays a crucial role in stimulating cellular growth, proliferation, and differentiation. They are essential for regulating various cellular processes and maintaining the health and vitality of the body. Growth factors specifically function by binding to receptors on the cell surface, triggering cellular changes.

HER2/neu is a gene that produces HER2 proteins, often associated with aggressive types of cancer, notably breast cancer. An overexpression of this gene can lead to rapid cell growth and division, contributing to tumor development. HER2-positive cancers are typically more advanced at diagnosis and require specific treatment approaches.

Hematocrit refers to a blood test that determines the proportion of red blood cells in your blood. It is often used to diagnose conditions such as anemia, dehydration, or diseases affecting red blood cell production. A higher or lower than normal hematocrit level may indicate medical conditions that need further evaluation.

Hemoglobin is a protein found in red blood cells responsible for carrying oxygen from the lungs to the body's tissues and returning carbon dioxide back to the lungs. It gives the blood its red color and helps maintain the body's overall health and vitality.

Hypercalcemia is a medical condition characterized by an abnormally high level of calcium in the blood. It can be caused by several factors such as hyperparathyroidism, certain types of cancer, or excessive intake of vitamin D. Symptoms may include frequent urination, fatigue, nausea, or bone pain. If left untreated, it can lead to serious complications, including kidney stones and cognitive issues.

Immunoglobulin refers to any class of proteins, produced by the immune system, that function as antibodies in the response to an invasion by foreign substances, such as bacteria and viruses. They play a crucial role in identifying and neutralizing these pathogens, enhancing immune responses.

Infertility is defined as the inability to achieve a successful pregnancy after a 12-month period of appropriately timed, unprotected intercourse. It is well established that it can result from various cancer treatments. Patients who received alkylating agents, cisplatin, and other heavy metal-containing chemotherapy are at risk. Radiation therapy to the hypothalamus/pituitary axis, ovaries, or testes has the potential to significantly increase this risk. One’s own fertility status can be checked via fertility tests but there is no absolute way to test for future fertility potential in either cancer survivors or the general population. Ovarian reserve tests only provide indirect estimates and do not predict natural fertility potential in regularly ovulating women, and likewise, semen analysis cannot absolutely predict sterility in males.

Adenocarcinoma is a type of cancer that starts in the glandular cells, which are found in various organs of the body. These cells secrete mucus, digestive enzymes, or hormones, among other substances. Adenocarcinomas can occur in different parts of the body, most commonly in the lungs, colon, prostate, and breasts. It is a malignant tumor and treatment varies depending on the location and stage of the disease.

Aneuploidy refers to an abnormality in the chromosome number in a cell, where there's either an excess or a deficiency of one or multiple chromosomes. This variation from the normal chromosome number (diploid) often leads to various genetic disorders. The most common example is Down syndrome, caused by an extra copy of chromosome 21.

"B-cell" refers to a type of white blood cell that plays a pivotal role in the immune system. B-cells can mature into cells that produce antibodies, specialized proteins that help fight infections, viruses and diseases. They also create immune memory, enabling the immune system to respond more efficiently to future exposures to the same pathogens.

A carcinogen refers to any substance, radionuclide, or radiation that promotes carcinogenesis, the formation of cancer. It works by altering the cellular metabolism or damaging DNA directly in cells, which in turn can induce the development of cancerous growths. Hence, exposure to carcinogens increases cancer risk. Examples include tobacco smoke, asbestos, and certain chemicals.

Ductal carcinoma refers to a common type of breast cancer that begins in the cells lining the milk ducts, which act as transport channels from the lobules, where milk is made, to the nipple. It can remain within the ducts as a non-invasive cancer (ductal carcinoma in situ) or it can spread beyond the ducts into the breast tissue (invasive ductal carcinoma).

Epithelial cells are a type of cell that lines the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. They serve as a barrier between the inside and outside of your body and have specialized functions including secretion, selective absorption, protection, transcellular transport and detection of sensation.

The estrogen receptor (ER) is a protein within cells that binds to the estrogen hormone. There are two types: ER-alpha and ER-beta. Upon binding, these receptors can alter gene expression, influencing cell growth and differentiation. They play significant roles in reproductive and non-reproductive systems, and can be involved in certain diseases, including breast cancer.

A Microarray is a laboratory tool used to detect the expression of thousands of genes simultaneously. It's a two-dimensional grid where probes (DNA or RNA fragments) are attached. By analyzing the way a sample interacts with these probes, scientists can measure the expression levels of massive quantities of genes, making it a crucial tool in genomics research.

Pediatric oncology is a medical specialty focused on the diagnosis and treatment of cancers occurring in children and adolescents. This branch combines various treatments like chemotherapy, radiation therapy, surgery and stem cell transplantation, along with research on cancer biology and genetics. The aim is to effectively treat and ideally achieve remission, while reducing potential side effects and improving the quality of life for young patients.

Platelets, also known as thrombocytes, are small, colorless cell fragments in our blood that form clots and stop or prevent bleeding. These essential components of the blood are produced in the bone marrow and serve a crucial role in blood coagulation, wound healing, and inflammation response.###

Recurrence refers to the act of occurring again or repeating. In a health context, it often refers to the return of a disease or condition after a period of improvement or apparent cure. It can also apply to repeated patterns or events in various other disciplines, such as mathematics, engineering, or computer science.