Pleomorphic Adenoma

Definition

Pleomorphic adenoma is a benign tumor that typically occurs in the salivary glands, most commonly in the parotid gland. It is characterized by a mix of different cell types and structures, hence the name 'pleomorphic.' While generally non-cancerous, it can become malignant if not treated.

Added:January 10, 2025

Updated:January 10, 2025

Overview

Pleomorphic adenoma, often referred to as a benign mixed tumor, is the most common type of salivary gland tumor. It primarily affects the parotid gland, which is located near the jaw and in front of the ears. This tumor is known for its diverse cellular makeup, which can include epithelial, myoepithelial, and stromal components.

Key Information

Pleomorphic adenomas account for approximately 60-70% of all salivary gland tumors. They are more frequently diagnosed in women and typically appear between the ages of 30 and 50. These tumors are usually slow-growing and present as painless, movable masses. Despite being benign, there is a risk of malignant transformation if left untreated over many years.

Clinical Significance

The medical importance of pleomorphic adenoma lies in its potential for malignant transformation, which can occur in about 2-10% of cases if not excised. The tumor's benign nature often leads to a good prognosis when surgically removed. However, incomplete removal can lead to recurrence.

Treatment & Management

The primary treatment for pleomorphic adenoma is surgical excision, ensuring complete removal to minimize recurrence risk. The type of surgery depends on the tumor's size and location, with superficial parotidectomy being a common approach for parotid gland tumors. Follow-up care is crucial to monitor for potential recurrence.

Patient Resources

Patients diagnosed with pleomorphic adenoma can access various resources for support and education. Organizations like the American Cancer Society and the National Cancer Institute provide information on salivary gland tumors. Support groups and counseling services can also help patients cope with the emotional aspects of their diagnosis.

Frequently Asked Questions

What causes pleomorphic adenoma?

The exact cause of pleomorphic adenoma is unknown, but it is believed to involve genetic mutations and environmental factors.

Is pleomorphic adenoma cancerous?

No, pleomorphic adenoma is a benign tumor, but it can become malignant over time if not treated.

What are the symptoms of pleomorphic adenoma?

Common symptoms include a painless lump near the jaw or neck, facial swelling, and sometimes facial nerve weakness if the tumor is large.

How is pleomorphic adenoma diagnosed?

Diagnosis is typically made through a combination of physical examination, imaging studies like MRI or CT scans, and a biopsy to confirm the tumor type.

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