Cancer-Related Dictionary

Affinity chromatography is a laboratory technique used to purify and separate proteins or other molecules from a mixture based on their specific interactions with a ligand attached to a stationary phase.

"Anterior Resection" refers to a surgical procedure typically performed on patients with rectal or colon cancer. It involves the removal of the affected part of the rectum or colon and then reattaching the remaining sections to restore digestive function. The procedure involves delicate and complex surgery aiming at retaining bowel function while removing the cancer.

Axillary node dissection is a surgical procedure to remove lymph nodes from the armpit area (axilla) to check for the spread of breast cancer or other diseases.

Axillary dissection is a surgical procedure used to remove lymph nodes found in the armpit region or "axilla", primarily performed on patients with breast cancer. This operation helps determine the stage of the cancer and guides treatment decisions by revealing if the cancer has spread to these lymph nodes.

A biopsy is a medical procedure in which a small sample of tissue is removed from the body for examination under a microscope to detect and diagnose diseases, specifically cancer. This diagnostic tool helps doctors understand the extent of the disease and determine the best treatment plan.

A "Biopsy Punch" is a medical device commonly used in dermatological procedures to obtain tissue samples for biopsy. It is typically a cylindrical, knife-like instrument, operated manually or spring-loaded, that is pressed into the skin to cut a small, round piece of tissue for microscopic examination. Designed with various sizes, it ensures a less invasive procedure with less discomfort for patients while providing accurate and rapid sampling.

Bone marrow is soft, spongy tissue found within the central cavities of bones. It is responsible for producing different types of blood cells, including red blood cells that carry oxygen, white blood cells that fight infections, and platelets that help with blood clotting. Essentially, the bone marrow serves as a vital part of the body's immune system and overall health.

A bone marrow biopsy is a medical procedure where a small sample of bone marrow, usually from the hip bone, is extracted for testing. It's often used to diagnose a variety of diseases, such as cancer, anemia, and infections. This procedure is generally done under a local anaesthetic to minimize discomfort.

Brachytherapy is a form of cancer treatment where radioactive seeds or pellets are directly inserted into the cancerous tissue, enabling a high radiation dose while reducing exposure to surrounding healthy tissues. It's often used for prostate, cervical, and breast cancers.

Breast reconstruction is a type of surgery performed on women who have had all or part of a breast removed. The procedure restores the breast to near normal shape, appearance, symmetry and size following mastectomy or lumpectomy. It's often carried out by a plastic surgeon using either implants or tissue from another area of the body. It plays a significant role in improving the quality of life and self-esteem of women who have undergone breast cancer treatment.

Bronchoscopy is a medical procedure that allows doctors to examine the patient's lungs and airways. It involves passing a thin viewing instrument called a bronchoscope through the patient's nose or mouth, down the throat, into the trachea, and into the bronchi. This procedure helps to diagnose lung diseases, tumors, infections, or blockages. It enables the collection of tissue or mucus samples for further testing.

Capsule endoscopy is a non-invasive diagnostic procedure involving a patient swallowing a small, pill-sized camera. The camera travels through the gastrointestinal tract, capturing images that help detect abnormalities such as polyps, inflammatory disease, or ulcers. It's typically used when traditional endoscopy is inconclusive or impractical.

A clinical trial is a scientific research process involving volunteers that tests the efficacy and safety of new medical treatments, drugs, and prevention strategies. It's a part of biomedical research designed to add to the medical knowledge base. The trials are usually carried out in successive phases, each with different objectives and testing different variant of the treatment.

A colonoscopy is a medical procedure that enables a doctor, usually a gastroenterologist, to examine the inner lining of the large intestine (colon and rectum). It involves inserting a long, flexible tube (colonoscope) into the rectum. This tube has a small video camera on the end, which sends images to a display monitor allowing for the detection of abnormalities or early signs of cancer.

A colostomy is a surgical procedure where a portion of the large intestine, or colon, is brought through the abdominal wall to create a stoma. It's done in response to various diseases or injuries to bypass a damaged part of the colon. The stoma serves as an alternative exit point for body waste, which is collected in an external pouch.

A core needle biopsy is a medical procedure where a needle is used to extract a small sample of tissue from an organ or mass in the body. The sample is examined under a microscope to diagnose diseases, like cancer. It is generally less invasive and causes less scarring than a surgical biopsy.

Cryotherapy is a therapeutic technique involving the application of extreme cold to treat various medical conditions such as skin diseases, sports injuries, or to promote overall wellness. It is also utilized in surgical procedures to destroy abnormal tissues. Regular sessions of cryotherapy are believed to boost immunity and metabolism, improve skin health and reduce inflammation.

Cystoscopy is a medical procedure that allows a doctor to examine the lining of the bladder and the tube that carries urine (urethra). It utilizes a hollow tube equipped with a lens (cystoscope), enabling the doctor to diagnose, monitor, and treat conditions affecting the urinary system. The procedure is typically conducted in a hospital or specialized clinic.

Cytology is a branch of biology that deals with the study of cells - their structures, functions, and behavior. It is crucial in understanding diseases at a cellular level, forming the foundation for medical practices such as cancer detection through the study of cell samples.

Debulking is a medical procedure used primarily in the treatment of cancer. It refers to the surgical removal of as much of the malignant tumor as possible, to lessen the bulk or reduce the total number of cancer cells. The goal is to increase the effectiveness of subsequent therapies (e.g., radiation, chemotherapy) or to alleviate symptoms.

Density-gradient centrifugation is a laboratory technique used to separate particles, such as cells or molecules, based on their density. By spinning a sample in a centrifuge with a gradient of densities, different components settle at different levels, allowing for their isolation and analysis.

Dental oncology is a specialized field of dentistry that focuses on the oral health care of patients who have cancer. It involves the diagnosis, prevention, and management of oral complications related to cancer and its treatment.

Ductal lavage is a medical procedure used to collect cells from the milk ducts of the breast. It involves flushing the ducts with a saline solution to obtain samples for analysis, primarily to assess the risk of breast cancer.

An echocardiogram is a non-invasive diagnostic test that uses ultrasound waves to create an image of the heart. It allows doctors to see the heart's size, shape, and motion, and evaluate its chambers, valves, and blood flow. This test aids in diagnosing heart diseases and determining treatment courses.

An endoscope is a medical instrument used for visual examination of internal body structures that are not visible to the naked eye. It comprises a flexible or rigid tube fitted with lens systems and a light source, allowing doctors to diagnose, monitor and surgically treat various conditions. It's regularly used to examine organs such as the stomach, colon, or lungs.

An excisional biopsy is a medical procedure where an entire lump or suspicious area is removed for diagnostic examination, primarily to rule out or confirm cancer. It is often performed under local anesthesia. The excised tissue is then analyzed by a pathologist for signs of disease.

A fecal occult blood test (FOBT) is a non-invasive medical screening exam used to detect the presence of hidden (occult) blood in the stool, not visible to the naked eye. This test is often used as an early detection method for colorectal cancer, as abnormal bleeding may be an indication of polyps or tumors.

Fine Needle Aspiration (FNA) is a medical procedure where a thin, hollow needle is inserted into a lump or suspicious area to extract a sample of cells or fluid for microscopic examination. Typically used in cancer diagnostics, it helps physicians accurately identify any abnormalities.

Flow cytometry is a biophysical technology used in cell counting, cell sorting, biomarker detection, and protein engineering. It allows simultaneous multi-parametric analysis of physical and chemical characteristics of up to thousands of particles per second. This technique is widely used in diagnosing health disorders, especially those related to the immune system and blood.

Gamma knife surgery is a type of non-invasive procedure used in neurosurgery. Utilizing targeted radiation beams, it accurately treats small to medium-sized lesions or abnormalities in the brain without any physical incision, hence minimizing collateral damage to the surrounding healthy tissues. It’s commonly used to treat brain tumors, epilepsy, trigeminal neuralgia, and Parkinson's disease.

"Informed consent" is a key principle in healthcare ethics that refers to the patient’s right to make decisions about their treatment. It occurs when a healthcare provider educates the patient about the benefits, risks and alternatives of a proposed procedure or treatment. The patient must comprehend the information, and voluntarily give consent, ensuring their full understanding and agreement to the procedure.

Intravenous (IV) refers to a method of delivering medications, fluids, or nutrients directly into a person's bloodstream through a vein, commonly via a needle or tube. It ensures rapid action and precise control over the amount of substance administered. Often used in hospitals or medical facilities for treatments, rehydration, or during surgeries.

A lobectomy refers to a type of surgery where a lobe or a portion of an organ is removed. It is most commonly associated with the removal of a lobe of the lung due to conditions such as lung cancer, but it can also apply to other organs like the thyroid, liver, or brain. The procedure aims to treat disease and improve health.

A lumpectomy is a surgical procedure performed to remove a discrete portion or "lump" of tissue, usually a breast tumor, from an afflicted individual. It is often employed as an effective treatment for early-stage cancer, retaining most of the breast tissue and offering a less invasive alternative to mastectomy.

Lymphatic mapping is a medical procedure used to identify the lymph nodes that are the first to receive drainage from a tumor. These nodes, called sentinel lymph nodes, are examined to determine if cancer has spread.

A mammogram is a specialized medical imaging procedure used to screen and diagnose breast diseases, primarily cancer, in women. It involves taking X-ray pictures of the breast to detect early signs of cancer, often before physical symptoms develop. Mammograms are recommended annually for women of certain age groups or those with increased risk.

A mastectomy is a surgical procedure performed to remove one or both breasts, often used as a treatment for breast cancer. The extent of tissue removal can vary, from partial (removing the cancerous part) to total (removing the entire breast). It is a critical decision usually made after considering other treatment options, risk factors, and personal preferences.

A "Modified Radical Mastectomy" refers to a surgical procedure for breast cancer treatment, where the entire breast, most underarm lymph nodes, and often the lining over the chest muscles are removed, but the chest muscles themselves are preserved. This procedure has lesser physical impact compared to a radical mastectomy, yet still offers extensive therapy for aggressive breast cancers.

Orchiectomy is a surgical procedure carried out to remove one or both testicles in males. This operation is typically utilized as a treatment method for testicular cancer or prostate cancer. The procedure can also be employed in cases of severe trauma to the testicles or as part of gender affirmation surgery.

Current ovarian reserve tests include hormonal markers and ultrasonographic markers.  Hormonal markers: are determined in the blood after a blood sample is taken. Suitable markers are FSH (follicle-stimulating hormone), estradiol, inhibin-B, and antimullerian hormone (AMH).  The measurement of FSH levels at 2 or 3 days after the onset of full menstrual flow has been used as a marker of ovarian reserve since the 1980s, based on its association with reproductive outcome. Elevated FSH values are associated with but not always predictive of poor ovarian response and failure to conceive. Estradiol is the natural estrogen of the woman and is responsible for the expression of the female secondary sexual characteristics. It is produced by granulosa cells of the ovarian follicles. Estradiol levels are commonly assessed during the early follicular phase and high levels indicate normal functioning. Inhibin is a peptide hormone with 2 subunits (Alpha and Beta). Inhibin-B is produced by granulosa cells of ovarian follicles and its levels vary during the menstrual cycle. Concentrations of inhibin-B decrease with age and during premature ovarian failure. AMH is a proteohormone and is produced by granulosa cells of the follicles. AMH shows little cycle fluctuation and correlates negatively with the progression of follicle loss and with a woman's age: the higher the AMH, the higher the follicle count.  Ultrasonographic markers: include the antral follicle count (AFC) and the measurement of ovarian volume, both assessed through ultrasound of the ovaries. The AFC describes the number of antral follicles in the ovaries measuring between 2–10mm. The greatest advantage of ultrasonographic markers of ovarian reserve is their non-invasiveness. Both markers exhibit an age-related decline.

A Pap smear, also known as a Papanicolaou test, is a medical screening procedure for cervical cancer in women. It involves collecting cells from the woman's cervix — the lower, narrow end of the uterus — to check for any cell abnormalities that could possibly evolve into cancerous cells. The test is generally recommended for women between the ages of 21 and 65.

A pathology report is an important medical document that presents findings from laboratory tests conducted on tissue or cell samples. This report is processed by a pathologist and often includes details such as diagnosis, severity, cell details, and suggestions for further treatment if necessary. Pathology reports assist healthcare professionals in providing appropriate disease management strategies.

Phlebotomy is a healthcare process that involves drawing blood from patients for various purposes such as medical testing, donations, or research. This procedure is typically performed by a phlebotomist, a specialized medical professional trained to collect blood samples correctly and safely.

Photodynamic Therapy (PDT) is a medical treatment method which uses light-sensitive compounds, activated under specific light to destroy abnormal cells or pathogens. Widely used to tackle cancers and severe skin conditions, the therapy selectively damages the targeted cells while sparing healthy ones.

A prophylactic mastectomy is a preventive surgical procedure performed to remove one or both breasts to minimize the risk of developing breast cancer. It is typically considered by individuals with a high risk of breast cancer due to genetic mutations or a strong family history of the disease.

Quantitative PCR (qPCR), also known as Real-Time PCR, is a molecular biology technique used to amplify and simultaneously quantify DNA in real time. The main benefit of qPCR over traditional PCR is its ability to detect the specific sequences during the phase of exponential amplification, making it more efficient and accurate for DNA analysis and cloning tasks.

A radical mastectomy is a surgical procedure aimed at breast cancer treatment. In this operation, the entire breast, chest muscles beneath it, and all the lymph nodes under the arm are removed. It was once the standard treatment, but less extensive surgeries are typically performed today.

The semen analysis is the most important test available to evaluate male fertility. To do this, one needs to provide a semen sample. In a laboratory, a drop of semen is examined under a microscope and the number (sperm count), shape (morphology), and mobility (movement) of the sperm are determined. Sperm count: Either >16 million per ml or a total of over 39 million per ejaculation is considered normal. Shape: At least 4% must have a normal shape. The head, the midpiece, and the tail of the sperm are assessed. Mobility: More than 42% of sperm need to move and more than 30% need to travel. Movement is classified as progressive (purposeful forward movement), non-progressive (local movement, circular movement), or immotile (no movement).

A sentinel lymph node biopsy is a surgical procedure used to determine if cancer has spread beyond a primary tumor into the lymphatic system. It involves identifying, removing, and examining the sentinel lymph nodes, which are the first nodes to which cancer cells are likely to spread from a primary tumor.

Sentinel node mapping is a medical procedure used to identify the first lymph node, known as the sentinel node, that cancer cells are most likely to spread to from a primary tumor. This technique helps doctors determine the extent of cancer spread and plan appropriate treatment.