Cancer Dictionary

Tomotherapy is a unique type of radiation therapy used in cancer treatment. It combines the precision of 3D imaging with rotational delivery of radiation, precisely targeting the tumor from all angles. This technique helps to minimize exposure to healthy tissue, thereby reducing side effects. Tomotherapy offers the advantage of adjusting doses to match a tumor’s size, shape and location.

Irinotecan is a type of chemotherapy drug, classified as a topoisomerase I inhibitor. This drug is used primarily in the treatment of cancers, including colorectal and lung cancer. It works by interfering with the replication of cancerous cells, thereby preventing their growth and spread. Irinotecan is commonly administered intravenously.

Genomic testing is a type of medical test that decodes the information within an individual's DNA. It examines the genetic makeup to identify genetic variants, which can help predict susceptibility to certain diseases, guide treatment plans, or evaluate how an individual might respond to certain drugs.

Acute Lymphoblastic Leukemia (ALL) is a rare type of cancer characterized by the rapid production of abnormal white blood cells in the bone marrow. These cells impede the production of normal blood cells, triggering symptoms like fatigue, fever, and bleeding. ALL is most common in children but can also occur in adults. Treatment often involves chemotherapy, radiation, targeted therapy, or stem cell transplant.

Adenopathy refers to the medical condition characterized by the abnormal enlargement of the lymph nodes, which are vital parts of the immune system. The swelling may be due to infections, chronic inflammatory conditions, or malignancies. It's often detected through physical examination or imaging studies.

Adjuvant chemotherapy is a treatment approach using drugs to kill cancer cells left in the body after primary treatments, such as surgery or radiation. This method is typically employed to lower the risk of cancer recurrence and improve the patient's overall survival rate.

Adolescents and Young Adults (AYA) is a term typically used in healthcare to denote a specialized group ranging from ages 15 to 39. This group experiences unique health issues, including specific cancers and mental health disorders, which may require distinct treatment strategies and healthcare models.

Allogeneic refers to cells, tissues, or organs that are sourced from a genetically different individual of the same species. In healthcare, it often describes donor material for transplants such as Allogeneic Stem Cell Transplant, where donor stem cells are introduced to the recipient to aid disease treatment.

Alopecia, also known as hair loss, is a medical condition that involves the thinning or complete loss of hair from areas where it normally grows. This can affect the scalp, face, and body, and can occur due to various factors including genetics, hormonal changes, immune system abnormalities, or as a side effect of certain treatments or medications.

Capsule endoscopy is a non-invasive diagnostic procedure involving a patient swallowing a small, pill-sized camera. The camera travels through the gastrointestinal tract, capturing images that help detect abnormalities such as polyps, inflammatory disease, or ulcers. It's typically used when traditional endoscopy is inconclusive or impractical.

Hypofractionation is a method used in radiation therapy where the total dose of radiation is divided into large doses and treatments are given less often than traditional radiation therapy. This approach minimizes the treatment duration, potentially enhancing the convenience and effectiveness of the therapy.

A prophylactic mastectomy is a preventive surgical procedure performed to remove one or both breasts to minimize the risk of developing breast cancer. It is typically considered by individuals with a high risk of breast cancer due to genetic mutations or a strong family history of the disease.

Aplastic anemia is a rare, serious blood disorder in which the body's bone marrow fails to produce enough new blood cells, leading to a deficiency in all three blood cell types: red blood cells, white blood cells, and platelets. This condition can lead to uncontrolled bleeding, increased susceptibility to infections, and constant fatigue. It can occur at any age, sometimes without known cause.

Anal cancer is a rare type of malignancy arising from the anal canal or rectum. It starts when healthy cells in or around the anus change and grow out of control, forming a mass. Risk factors include increasing age, history of HPV infections, and smoking. Symptoms may include rectal bleeding, pain, or changes in bowel movements. Treatment often involves chemotherapy, radiation, or surgery.

"Anaplastic" is a term often used in the medical field, particularly in oncology, to describe cancer cells that have lost their distinct characteristics and appear undifferentiated. These cells exhibit irregular growth and lack the typical specialized features of healthy cells, often making the disease more aggressive and harder to treat.

Androgen is a type of hormone that plays a crucial role in the development and maintenance of male characteristics in mammals. It includes hormones like testosterone and dihydrotestosterone, which are produced primarily in male testes and female ovaries to regulate sexual development, muscle mass, bone density, and hair growth.

Anemia is a medical condition characterized by a deficiency in red blood cells or hemoglobin in the blood, leading to a lack of oxygen reaching the body's tissues. Hemoglobin is responsible for carrying oxygen, so any insufficiency can cause fatigue, weakness, and shortness of breath. Anemia can be temporary or long-term, and range from mild to severe. It's important to diagnose and treat anemia to handle any underlying causes and to prevent further health problems.

Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing ones. Predominantly occurring during development, wound healing, and the formation of granulation tissue, it's also a critical step in the transition of tumors from a benign state to a malignant one.

Angiosarcoma is a rare, malignant tumor that originates from endothelial cells, the cells that line the interior surface of blood vessels. It can occur anywhere in the body, but is most commonly found in the skin, breast, liver, spleen, and deep tissue. Due to its aggressive nature, it often leads to a poor prognosis. This tumor presents unique challenges due to its high recurrence rate and resistance to treatment.

"Anterior Resection" refers to a surgical procedure typically performed on patients with rectal or colon cancer. It involves the removal of the affected part of the rectum or colon and then reattaching the remaining sections to restore digestive function. The procedure involves delicate and complex surgery aiming at retaining bowel function while removing the cancer.

Anti-emetic refers to a type of medication used primarily to prevent or treat nausea and vomiting, symptoms often associated with motion sickness, chemotherapy, radiation, and surgery. Such drugs work by blocking neurotransmitters that trigger these unpleasant sensations. Thus, they are critical in the management of postoperative and chemotherapy-induced nausea and vomiting.

Anti-estrogen refers to a substance that blocks the production or utilization of estrogens, or inhibits their effects. They are commonly used in treatments for hormonal imbalances, such as those related to menopause, or for certain types of hormone-receptor-positive breast cancer.

Asbestos is a naturally occurring mineral that has heat-resistant properties. It was widely used in construction and manufacturing due to its strength and fire-resistant qualities. However, its fibers can cause serious health issues, like lung cancer and mesothelioma, when inhaled or ingested, leading to its ban in many countries.

Asparaginase is a therapeutic enzyme used in medical treatment, particularly in the management of acute lymphoblastic leukemia (ALL). It functions by breaking down asparagine, an amino acid crucial for cell growth, thereby inhibiting the proliferation of malignant cells that rely heavily on asparagine.

Axillary dissection is a surgical procedure used to remove lymph nodes found in the armpit region or "axilla", primarily performed on patients with breast cancer. This operation helps determine the stage of the cancer and guides treatment decisions by revealing if the cancer has spread to these lymph nodes.

BRCA1/BRCA2 are genes that produce proteins suppressing tumor growth. Mutations in these genes can lead to increased risk of certain cancers, primarily breast and ovarian in women. BRCA genetic testing helps identify these mutations, crucial for cancer prevention and treatment strategies.

Basal cells are a type of cell found at the bottom layer of the skin, known as the epidermis. These cells are responsible for skin regeneration, producing new skin cells and pushing older cells upward. Abnormal growth of basal cells can lead to basal cell carcinoma, the most common type of skin cancer.

"Benign" refers to a condition, tumor, or growth that is not harmful in effect and not malignant. It is non-cancerous and does not spread to other parts of the body. It denotes a mild form or consequence that does not typically become life-threatening or seriously damaging. In healthcare, benign is often associated with a positive prognosis.

Beta Human Chorionic Gonadotropin (Beta HCG) is a hormone produced by cells that are associated with pregnancy. It's usually detected in blood tests or urine tests to confirm pregnancy or as part of a screening test for certain birth defects. It can also be used in medical diagnostics to detect some cancers.

A biopsy is a medical procedure in which a small sample of tissue is removed from the body for examination under a microscope to detect and diagnose diseases, specifically cancer. This diagnostic tool helps doctors understand the extent of the disease and determine the best treatment plan.

A "Biopsy Punch" is a medical device commonly used in dermatological procedures to obtain tissue samples for biopsy. It is typically a cylindrical, knife-like instrument, operated manually or spring-loaded, that is pressed into the skin to cut a small, round piece of tissue for microscopic examination. Designed with various sizes, it ensures a less invasive procedure with less discomfort for patients while providing accurate and rapid sampling.

Bone marrow is soft, spongy tissue found within the central cavities of bones. It is responsible for producing different types of blood cells, including red blood cells that carry oxygen, white blood cells that fight infections, and platelets that help with blood clotting. Essentially, the bone marrow serves as a vital part of the body's immune system and overall health.

A brain tumor is an abnormal growth or mass of cells within the brain. These tumors can be either benign (non-cancerous) or malignant (cancerous) and can originate from the brain tissue itself or from other parts of the body, spreading to the brain. The presence of a brain tumor can disrupt normal brain function by compressing surrounding structures, causing neurological symptoms, and potentially leading to serious health issues. Diagnosis and treatment of brain tumors involve various medical interventions, such as imaging studies, surgery, radiation therapy, and chemotherapy, depending on the type, location, and characteristics of the tumor.

Breast cancer is a malignancy originating in the breast tissue, where cells begin to grow uncontrollably, forming a tumor. This tumor can potentially invade nearby tissues and, if left untreated, can spread to distant parts of the body through the bloodstream or lymphatic system. It is the most common cancer among women globally. Detecting breast cancer early through regular screenings like mammograms and employing a range of treatments such as surgery, chemotherapy, radiation, and targeted therapies can significantly improve the chances of successful treatment and recovery.

Astrocytoma is a type of brain tumor that originates from astrocytes, the star-shaped cells that make up the supportive tissue of the brain. These tumors can occur in various parts of the brain and spinal cord. Astrocytomas vary in their level of aggressiveness, ranging from benign (non-cancerous) to malignant (cancerous).

Cancer Stage (I, II, III, IV) refers to the extent of cancer spread in the body, determined by the size and location of the tumor, lymph node involvement, and whether the disease has metastasized. Stage I usually indicates a small tumor confined to the origin site. Stage II and III show larger tumors or greater spread to nearby tissues and nodes. Stage IV symbolizes advanced cancer that has spread to distant parts of the body.

Carcinoma is a type of cancer that starts in cells making up the skin or the tissue lining organs, such as the liver or kidneys. Unlike sarcomas, carcinomas originate in epithelial cells, including those in glandular tissues. These cancers can affect many parts of the body, often leading to specific symptoms based on their location and stage. Treatment typically involves a combination of surgery, radiation, and chemotherapy.

Carcinoma of unknown primary (CUP) is a rare disease where cancer cells are found in the body but the place the cancer began, known as the primary site, cannot be determined. Often, the cancer is already advanced by the time it's diagnosed. Early detection and accurate diagnosis of the primary site can aid in targeted treatment.

A colonoscopy is a medical procedure that enables a doctor, usually a gastroenterologist, to examine the inner lining of the large intestine (colon and rectum). It involves inserting a long, flexible tube (colonoscope) into the rectum. This tube has a small video camera on the end, which sends images to a display monitor allowing for the detection of abnormalities or early signs of cancer.

Colorectal cancer is a type of cancer that begins in the colon or rectum, parts of the large intestine in the digestive system. It typically starts as small, benign clumps of cells called polyps that can, over time, develop into cancers. Early detection through routine screenings can help prevent the progression of colorectal cancer.

A "Complete response" in a healthcare context typically refers to the total disappearance of all detectable signs and symptoms of disease, often as a result of treatment. It indicates a positive outcome where the individual shows no further evidence of the illness. However, it doesn't guarantee that the disease is permanently cured. It's an important effect reported in clinical trials and cancer treatment.

Non-Hodgkin lymphoma (NHL) refers to a group of various malignant cancers that develop in the lymph system, which is part of the body's immune system. Unlike Hodgkin lymphoma, NHL types are identified by various unique genetic marker abnormalities. These cancers can originate anywhere in the body and spread to any tissue or organ. It exhibits diverse symptoms and can proceed at varying rates, depending on the type.

Oral cancer refers to any cancerous tissue growth located in the mouth. It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity or the maxillary sinus. Early detection significantly increases the chances of a successful treatment.

Computed tomography (CT) is a medical imaging technique used to visualize internal structures of the body in detail. It combines a series of X-ray images taken from different angles and uses computer processing to create cross-sectional images, or slices, of bones, blood vessels, and soft tissues. CT provides more detailed information than standard X-rays.

"Cribriform" is a term used in anatomy and histology, referring to a structure that appears perforated or sieve-like. The term is frequently used to describe a structural pattern characterized by numerous round, small openings - resembling a sieve. This term is often mentioned with the cribriform plate of the ethmoid bone in the skull or in pathological processes like cribriform carcinoma.

Cytology is a branch of biology that deals with the study of cells - their structures, functions, and behavior. It is crucial in understanding diseases at a cellular level, forming the foundation for medical practices such as cancer detection through the study of cell samples.

DNA, short for Deoxyribonucleic Acid, is a vital molecule found in all living organisms. It contains the unique genetic code that determines the traits of a living being. Structured in a double helix shape, DNA contains pairs of nucleotides, which form genes, the basic units of heredity.

Debulking is a medical procedure used primarily in the treatment of cancer. It refers to the surgical removal of as much of the malignant tumor as possible, to lessen the bulk or reduce the total number of cancer cells. The goal is to increase the effectiveness of subsequent therapies (e.g., radiation, chemotherapy) or to alleviate symptoms.

"Hormone Receptor Status" refers to a clinical parameter determined in patients with certain types of cancers. It reveals whether the patient's cancer cells express specific proteins (hormone receptors) like estrogen and progesterone, signifying their dependency on these hormones for growth. This information influences the selection of optimal therapeutic strategies, informing decisions on hormone therapy use.

CA 19-9, or Carbohydrate Antigen 19-9, is a tumor marker primarily used to monitor treatment response and disease recurrence in pancreatic cancer patients. It can also be elevated in other gastrointestinal cancers and conditions such as cirrhosis and pancreatitis. It's not recommended for cancer screening in asymptomatic individuals due to non-specific findings.