Cancer Dictionary

Invasive lobular carcinoma (ILC) is a type of breast cancer that starts in the milk-producing glands (lobules) and can spread to other parts of the body. It's the second most common type of breast cancer, accounting for about 10% of all cases. Unlike other types, ILC tends to occur in both breasts simultaneously.

Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive form of blood cancer that primarily affects children under six years of age. It is characterized by the overproduction of immature white blood cells (myelomonocytes) in the bone marrow, impairing the production of essential blood cells and leading to severe complications such as anemia, infection, bleeding, and organ dysfunction.

Kidney cancer is a type of malignancy that originates in the kidneys, specifically in the small tubes within them. Variations include renal cell carcinoma and transitional cell carcinoma. It is often discovered in the early stages when there are few, if any, symptoms. Risk factors include smoking, obesity, and high blood pressure. Treatment may involve surgery, radiotherapy, or targeted therapies.

Laryngeal cancer is a type of throat cancer that specifically impacts the voice box, or larynx. It typically forms in squamous cells lining the larynx, affecting breathing, swallowing and voice quality. Risk factors include smoking, excessive alcohol, and certain strains of HPV. Treatment often involves surgery, radiation or chemotherapy. As an aggressive disease, early detection significantly improves prognosis.

Liposarcoma is a rare type of cancer that originates in the fat cells. It often affects the limbs or the abdomen but can manifest in other parts of the body. Its growth may be slow and initially unnoticed, but it can eventually interfere with organ function or movement. Treatment options typically involve surgery, radiation therapy, or chemotherapy.

Lobular carcinoma is a type of breast cancer that originates from the lobules, which are the glands that produce milk in the breast. It's the second most common type of breast cancer, often growing more slowly and less likely to form a lump than the more common type, ductal carcinoma. Largely affecting postmenopausal women, it can also spread to other parts of the body.

Lymphoma is a type of cancer that originates in the lymphatic system, an essential component of the body's immune system. It specifically develops in lymphocytes, a type of white blood cell that fights infections. There are two main types - Hodgkin lymphoma and non-Hodgkin lymphoma. Symptoms typically include swollen lymph nodes, fatigue, and unexplained weight loss.

Medulloblastoma is a type of aggressive, fast-growing brain cancer that primarily affects children. It begins in the cerebellum, the part of the brain responsible for balance, coordination, and complex intellectual functions. Early detection and treatment are crucial for improving survival rates and outcomes. Despite its severity, advancements in therapy have increased the survival rate significantly.

Merkel cell carcinoma (MCC) refers to a rare and aggressive type of skin cancer that typically begins in the hormone-producing cells just beneath the skin and hair follicles. It commonly appears as a flesh-colored or bluish-red nodule and usually develops on sun-exposed areas. While MCC can occur at any age, it predominantly affects seniors and those with a weak immune system.

Multiple myeloma is a type of blood cancer that originates from plasma cells, a type of white blood cell responsible for the production of antibodies. In this condition, these cells become malignant, multiply uncontrollably, and accumulate in the bone marrow, interfering with the production of healthy blood cells.

Nasopharyngeal carcinoma is a type of cancer that occurs in the nasopharynx, the area at the upper part of the throat behind the nose and near the base of the skull. It is characterized by the abnormal growth of cells in the squamous cells lining the nasopharynx. This type of cancer is rare in most parts of the world but is more common in certain regions, particularly in Southeast Asia.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 85% of all cases. It typically grows and spreads more slowly than small cell lung cancer. There are three main types which include; squamous cell carcinoma, adenocarcinoma and large cell carcinoma. NSCLC usually begins in cells lining the lungs and can often be successfully treated if caught early.

Oligodendroglioma is a type of brain tumor arising from oligodendrocytes, cells that produce myelin - an insulating layer around neurons. This slow-growing tumor generally affects adults and is often found in the frontal lobe of the brain. Symptoms include persistent headaches, seizures, and changes in personality or mental capacity. Treatment typically involves surgery, chemotherapy, and radiation therapy.

Prostate cancer is a medical condition characterized by abnormal growth of cells in the prostate gland, a tiny walnut-shaped organ present in males, responsible for semen production. It's one of the most prevalent types of cancer among men and can vary from slow-growing to aggressive, potentially metastasizing to other body parts if left untreated. Risk factors include age, family history, race, and certain dietary habits.

Rectal cancer is a disease in which malignant (cancerous) cells form in the tissues of the rectum. The rectum is the last several inches of the large intestine. It often manifests with symptoms like persistent change in bowel habits, rectal bleeding or blood in stool, persistent abdominal discomfort, and unexplained weight loss. Early diagnosis aids effective treatment.

Testicular cancer is a type of malignancy that originates in the testicles, which are male reproductive organs producing sperm and hormones. This condition, while rare compared to other cancers, is the most common cancer in American men aged 15-35. It's highly treatable, often curable, but early detection is crucial for better prognosis and recovery.

Triple-negative breast cancer (TNBC) refers to a subtype of breast cancer characterized by the absence of estrogen, progesterone, and HER2 receptors, making it less responsive to hormonal therapies. This type of cancer is often more aggressive and has a higher risk of recurrence compared to other types, requiring specialized treatment strategies.

Mesothelioma is a rare, aggressive type of cancer that primarily forms on the protective lining of the lungs, abdomen, or heart. It's typically caused by exposure to asbestos, a microscopic, fibrous mineral. With symptoms often appearing decades after exposure, diagnosis is normally in the later stages, impacting prognosis and treatment options.

Small cell lung cancer is a fast-growing type of lung cancer usually caused by smoking. It typically starts in the bronchi, quickly spreads throughout the body, and manifests with symptoms such as cough, chest pain, and shortness of breath. Treatment options include chemotherapy, radiation therapy, and surgery. This cancer represents about 10 -15% of all lung cancers.

Colon cancer, also known as colorectal cancer, is a malignant disease that starts in the cells of the colon or rectum. It typically begins as small, noncancerous cells (polyps) that may over time develop into cancer. Symptoms can include changes in bowel habits, blood in stool, and persistent abdominal discomfort. Early detection through screening can often lead to successful treatment.

Uterine cancer refers to a type of cancer that begins in the uterus, the pear-shaped organ in a woman's pelvis where fetal development occurs. It primarily affects postmenopausal women and it's typically caused by cells growing uncontrollably. The two main types are endometrial cancer (most common, starts in the uterus lining) and uterine sarcoma (rare, begins in the muscle). Early diagnosis and treatment are crucial for effective management.

Secondary malignancies are new cancers that occur in a person who has previously been diagnosed with cancer. These are not recurrences of the original cancer but entirely new types of cancer that develop as a result of the initial cancer treatment, genetic predisposition, or other risk factors.

Sessile serrated lesions are a type of growth found in the colon that can potentially develop into cancer. They are characterized by a flat, broad base and a saw-tooth appearance under a microscope. These lesions are considered precancerous and are often detected during routine colonoscopies.

Cancer organoids are three-dimensional cell cultures derived from a patient's tumor cells. These organoids mimic the structure and function of actual tumors, allowing researchers to study cancer in a laboratory setting more effectively. They provide a personalized approach to understanding cancer biology and testing potential treatments.

Pulmonary metastases refer to cancer cells that have spread from a primary tumor located in another part of the body to the lungs. This process is known as metastasis, and it indicates that the cancer is at an advanced stage.

Acinar cell carcinoma is a rare type of cancer that originates in the acinar cells of the pancreas, which are responsible for producing digestive enzymes. It is characterized by the abnormal growth of these cells, leading to the formation of a tumor in the pancreas.

Adenocarcinoma in situ is a type of cancer where abnormal cells are found in the glandular tissue lining but have not spread to nearby tissues. It is considered an early form of cancer and is often treatable if detected early.

Ameloblastoma is a rare, benign tumor that typically occurs in the jaw near the molars. It originates from cells involved in tooth development and can cause swelling and pain in the affected area. Although benign, it can be aggressive and invade nearby bone and tissue.

Anaplastic ependymoma is a rare and aggressive type of brain tumor that originates from ependymal cells lining the ventricles of the brain and the central canal of the spinal cord. It is characterized by rapid growth and a tendency to spread within the central nervous system.

Anaplastic oligodendroglioma is a rare and aggressive type of brain tumor that originates from oligodendrocytes, which are cells that support nerve cells in the brain. It is characterized by its rapid growth and tendency to spread, making it more challenging to treat compared to other types of brain tumors.

Central nervous system lymphoma is a rare type of cancer that occurs in the lymph tissue of the brain and spinal cord. It involves the uncontrolled growth of lymphocytes, a type of white blood cell, within the central nervous system.

Colorectal adenoma is a type of non-cancerous (benign) tumor that forms in the lining of the colon or rectum. These growths are considered precursors to colorectal cancer, meaning they have the potential to become cancerous over time if not removed.

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive type of cancer that typically occurs in the abdomen. It primarily affects adolescents and young adults and is characterized by small, round cancer cells surrounded by dense fibrous tissue.

Endometrial stromal sarcoma is a rare type of cancer that originates in the connective tissue cells of the endometrium, which is the lining of the uterus. It is characterized by abnormal and uncontrolled growth of these cells, which can invade surrounding tissues and spread to other parts of the body.

Epidermal carcinoma is a type of skin cancer that originates in the epidermis, the outermost layer of the skin. It involves the uncontrolled growth of abnormal cells in this layer, leading to the formation of tumors. This condition is often associated with prolonged exposure to ultraviolet (UV) radiation from the sun or tanning beds.

Extranodal lymphoma is a type of cancer that originates in lymphocytes, a kind of white blood cell, but occurs outside the lymph nodes. It can affect organs such as the stomach, skin, and brain.

Extrathyroidal extension refers to the spread of thyroid cancer beyond the thyroid gland into surrounding tissues. This can affect treatment options and prognosis.

Follicular carcinoma is a type of thyroid cancer that arises from the follicular cells of the thyroid gland. It is generally slow-growing and often has a good prognosis when detected early.

Gliosarcoma is a rare and aggressive type of brain tumor that contains both glial and sarcomatous components. It is a variant of glioblastoma and typically occurs in adults, often presenting with symptoms such as headaches, seizures, and neurological deficits.

Indolent lymphoma is a type of cancer that affects the lymphatic system. It is characterized by slow growth and progression, which means it often takes years to become serious. Despite its slow nature, it can still require treatment and monitoring.

Lymphomatoid papulosis is a rare skin disorder characterized by recurring, self-healing skin lesions that resemble lymphoma but are typically benign. These lesions can appear as red-brown bumps or nodules on the skin and may last for weeks or months before resolving on their own.

Marginal zone lymphoma is a type of slow-growing non-Hodgkin lymphoma that originates in the marginal zone of lymphoid tissue, which is part of the immune system. It often affects the spleen, lymph nodes, or mucosa-associated lymphoid tissue (MALT) and is characterized by the abnormal proliferation of B-cells.

Mediastinal lymphoma is a type of cancer that occurs in the lymph nodes located in the mediastinum, the central part of the chest between the lungs. It involves the abnormal growth of lymphocytes, which are a type of white blood cell, and can affect the body's immune system.

Melanoma in situ is an early form of skin cancer where the malignant cells are confined to the outermost layer of the skin, known as the epidermis. It is the earliest stage of melanoma and is highly treatable when detected early.

Non-invasive cancer, also known as in situ cancer, is a type of cancer that has not spread beyond the layer of cells where it initially developed. It remains confined to the place of origin and has not invaded neighboring tissues or metastasized to other parts of the body.

Peritoneal carcinomatosis is a condition where cancer cells spread to the peritoneum, the lining of the abdominal cavity. This often occurs in advanced stages of abdominal cancers such as ovarian, gastric, or colorectal cancer, leading to symptoms like abdominal pain, bloating, and weight loss.

Pleomorphic adenoma is a benign tumor that typically occurs in the salivary glands, most commonly in the parotid gland. It is characterized by a mix of different cell types and structures, hence the name 'pleomorphic.' While generally non-cancerous, it can become malignant if not treated.

Rare cancers are types of cancer that occur infrequently, affecting a small percentage of the population. They can be challenging to diagnose and treat due to limited research and awareness.

Refractory cancer is a type of cancer that does not respond to treatment. It may continue to grow or spread despite therapy, making it challenging to manage.

Retroperitoneal sarcoma is a rare type of cancer that develops in the connective tissues located in the retroperitoneal space, an area in the back of the abdomen behind the peritoneum, which is the lining of the abdominal cavity. These tumors can grow quite large before causing symptoms, as they have space to expand in the retroperitoneal area.